Custom Search


Friday 16 February 2007

Graft-vs.-host disease in lung and other solid organ transplant recipients.

By: Assi MA, Pulido JS, Peters SG, McCannel CA, Razonable RR.

Clin Transplant 2007 Jan-Feb;21(1):1-6

Graft-vs.-host disease (GVHD) is an uncommon complication of solid organ transplantation. Herein, we report a case of GVHD occurring in a lung transplant recipient and review 29 reported cases of GVHD that complicated thoracic organ, and non-hepatic intra-abdominal organ transplantation. The major presenting clinical symptom of GVHD was skin rash. Less frequent clinical manifestations were cytopenia (16%), diarrhea (11%), and fever (5%). The mainstay of treatment was high-dose corticosteroids. The mortality rate was high (30%). The cause of death was mainly due to infection, suggesting that antimicrobial prophylaxis may improve the outcome of this potentially fatal complication.

Use of this site is subject to the following terms of use