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Why is this medication prescribed?

Prochlorperazine is used to treat the nausea and vomiting caused by radiation therapy, cancer chemotherapy, surgery, and other conditions. It is also used to treat psychotic symptoms such as hallucinations, hostility and non-psychotic anxiety (nervousness).

This medicine is a highly potent neuroleptic, which is 10-20 times more potent than chlorpromazine. Prochlorperazine is in a class of drugs called phenothiazines.

Mechanism:

Prochlorperazine acts by blocking a variety of receptors in the brain, particularly dopamine receptors. Dopamine is involved in transmitting signals between brain cells. When there is an excess amount of dopamine in the brain it causes over-stimulation of dopamine receptors. These receptors normally act to modify behaviour, and over-stimulation may result in psychotic illness. Prochlorperazine blocks these receptors and stops them becoming over-stimulated, thereby helping to control psychotic illness.

Although prochlorperazine can be used in the control of psychotic conditions such as schizophrenia, it also affects receptors in an area of the brain that controls nausea and vomiting.

 

FDA Information

Other uses for this medicine

Dosage and using this medicine

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What should I do if I forget a dose?

What side effects can this medication cause?

What storage conditions are needed for this medicine?

In case of an emergency/overdose

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